Clinical trials and research studies on abdominal aortic aneurysm - Abdominal aortic aneurysm development is closely linked to hemodynamics detailing specific characteristics of different parts of aorta. Age plays a major role in abdominal aortic aneurysm.
Clinical Trials and Research Studies on Abdominal Aortic Aneurysm
New York (USA), June 16, 2013
Clinical Trials and Research Studies
Abdominal aortic aneurysm development is closely linked to hemodynamics detailing specific characteristics of different parts of aorta. Infrarenal aorta or the part of aorta that is in the abdominal region has different characteristics than aorta of thoracic region.
Abdominal aorta walls contain lesser proportion of elastin and diameter decreases from root to bifurcation. These walls have higher mechanical tension. However, age plays a major role in abdominal aortic aneurysm. Dilation sustainability and elasticity of body parts including aorta decline as you age. Gradually, aorta is unable to bear excessive pressure of blood. The situation is markedly progressive if you have high arterial hypertension and intraluminal pressure. All together decide condition of aorta and thereby comment on progress of abdominal aortic aneurysm.
In aneurysmatic aorta, there are few explicit changes. These include calcifications, ruptures, and ulcerations of layers, accumulation of lipids in foam cells, thrombosis, inflammatory infiltrate, and extracellular free cholesterol crystals. Research indicates continued degradation through proteolysis process is the prime mechanism of abdominal aortic aneurysm. In some cases, elastin elimination causes aorta walls to be more susceptible to blood pressure in abdominal region. Nutrition levels fall and aorta is more prone to damage.
Research also indicates increased incidence of abdominal aortic aneurysm in men in the age of 65 to 75 years who have been smokers at any time of their lives. However, regular checkups and continued treatment does yield positive results.
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