Acute lymphocytic leukemia is the most common type of childhood cancer. Acute lymphocytic leukemia spreading across spinal cord and brain has high mortality. Cytogenetic studies elaborate changes in chromosomes of cancer cells.
Clinical Trials and Research Studies on Acute Lymphocytic Leukemia
New York (USA), June 25, 2013
Acute Lymphocytic Leukemia: Clinical Trials and Research Studies
Acute lymphocytic leukemia is the most common type of childhood cancer. It affects children between two to five years the most. Incidence decreases with increase in age. Again, incidence peaks after the age of fifty, more so in males.
Damage to DNA is the primary cause for acute lymphocytic leukemia.
This damage alters chemical and growth patterns in cells. Hence, cells continue to multiply uninterruptedly. Damage to DNA could be due to formation of fusion genes, deregulation of a proto-oncogene, or contradictory reaction of T-cell receptor gene. Radiation and exposure to chemicals or drugs causes such damage.
Improvements in stem cell transplantation technology, matching treatment according to genetic characteristics of blast cells, new drugs, and innovative clinical trials on chemotherapeutic agents have enhanced survival rates of acute lymphocytic leukemia appreciably.
Acute lymphocytic leukemia spreading across spinal cord and brain has high mortality. If you also have Down’s syndrome, prognosis is still graver. Cytogenetic studies elaborate changes in chromosomes of cancer cells. Translocation between chromosomes 4 and 11 is common in infants while Philadelphia chromosome causes translocation between chromosomes 9 and 22. These translocations are fatal. However, not all translocations are fatal. Few offer much better mortality rates.
Ponatinib is the most recently approved drug for treating Ph+ ALL patients. Studies show that within six months of treatment with this drug, some patients with CML/Ph+ ALL could achieve normal white blood cell count.
Acute Lymphocytic Leukemia – Definition and Diagnosis
Definition and Diagnosis of Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Causes and Evaluation
Causes and Evaluation of Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Signs and Symptoms
Signs and Symptoms of Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Complications and Risk Factors
Complications and Risk Factors for Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Diagnostic Tests and Procedures
Diagnostic Tests and Procedures for Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Treatments and Medications
Treatments and Medications for Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Home Remedies and Alternative Therapies
Home Remedies and Alternative Therapies for Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Prevention and Coping
Prevention and Coping with Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Lifestyle Changes and Self-Help
Lifestyle Changes and Self-Help for Acute Lymphocytic Leukemia
Acute Lymphocytic Leukemia – Prevention, Treatment, and Remedies
Acute Lymphocytic Leukemia – Causes, Symptoms, Diagnosis, Prevention, Treatment, and Remedies