Complications and risk factors of acute myelogenous leukemia include gender, age, smoking, cancer treatment in the past, radiation exposure, blood disorders. Men are more prone to acute myelogenous leukemia than women are.
Complications and Risk Factors for Acute Myelogenous Leukemia
New York (USA), June 25, 2013
Acute Myelogenous Leukemia: Complications and Risk Factors
Anything that makes you susceptible to specific disease is termed a risk factor. Nonetheless, risk factors are not mandatory for occurrence of a disease. Some do not have any risk factors yet contract the disease while some have many risk factors but do not contract the disease.
Complications and risk factors of acute myelogenous leukemia include:
Gender: Men are more prone to acute myelogenous leukemia than women are, although there is no specific reason behind this occurrence.
Age: Acute myelogenous leukemia normally affects adults over the age of sixty-five. Risk increases as you age.
Smoking: Cigarette smoke contains benzene and various carcinogenic chemicals. If you smoke, you are at a higher risk of acute myelogenous leukemia.
Cancer Treatment in the Past: If you have undergone chemotherapy treatment in the past for any type of cancer, you are at a risk for acute myelogenous leukemia. Chemotherapy involves use of alkylating agents and topoisomerase-II inhibitors. Alkylating agents expose you to a myelodysplastic phase before acute myelogenous leukemia starts developing. Topoisomerase-II inhibitors cause translocations in chromosomes commonly in band 11q23. Normally, latency period between exposure to alkylating agents and acute myelogenous leukemia is three to five years. However, this latency period is well within a year for topoisomerase-II inhibitors.
Radiation Exposure: High levels of radiation could cause acute myelogenous leukemia. If you have undergone radiation treatment for any other disorder like ankylosing spondylitis, or have been exposed to environmental radiation, you could develop acute myelogenous leukemia.
Exposure to Dangerous Chemicals: Certain chemicals like benzene used as a solvent in oil refineries and other industries, detergents, cleaning products, and paint strippers are harmful. Exposure to such chemicals on a regular basis could lead to acute myelogenous leukemia.
Blood Disorders: If you have had blood disorders like myelofibrosis, polycythemia Vera, aplastic anemia, Myelodysplasia, paroxysmal nocturnal hemoglobinuria or thrombocythemia in the past, you could develop acute myelogenous leukemia later.
Genetic Disorders: Down syndrome, congenital neutropenia, Bloom syndrome, neurofibromatosis, Fanconi’s anemia, and similar genetic disorders put you at a risk of developing acute myelogenous leukemia. Often such patients develop acute myelogenous leukemia in childhood itself. In very rare cases, they develop it as adults.
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