Myleoblast is malignant cell in acute myelogenous leukemia. There are stages of acute myelogenous leukemia due to leukemic transformations taking place. Pathophysiology in acute myelogenous leukemia is maturational arrest of bone marrow cells.
Clinical Trials and Research Studies on Acute Myelogenous Leukemia
New York (USA), June 25, 2013
Acute Myelogenous Leukemia: Clinical Trials and Research Studies
Myleoblast is the malignant cell in acute myelogenous leukemia. In normal circumstances, myleoblast is the immature stage of myeloid white blood cells, which eventually would mature into a white blood cell. However, during acute myelogenous leukemia, a single myleoblast undergoes many genetic changes and therefore myleoblast remains in its immature state. Nonetheless, this does not lead to acute myelogenous leukemia. Instead, many other mutations combine and disrupt regular genetic functions. This causes uncontrolled growth of immature clone cells eventually causing acute myelogenous leukemia.
The underlying pathophysiology in acute myelogenous leukemia is maturational arrest of bone marrow cells right from the time these cells start developing. This mechanism is still being deciphered. Sometimes it is due to activation of abnormal genes through genetic abnormalities and chromosomal translocations.
Such stoppage of development of cells leads to two distinct disease processes. Normal blood cell production decreases significantly. This causes anemia, neutropenia, and thrombocytopenia. Fast and extensive increase of leukemic cells with decreased ability of apoptosis or death during cell division jams blood, bone marrow, spleen, and liver. Sometimes it also spreads to spinal cord and brain.
There are different stages of acute myelogenous leukemia due to leukemic transformations taking place across different levels of cell growth. Rather, each cell depicts characteristics of specific stage at which growth was halted. Hence, there is no synchronization in cell growth and development in acute myelogenous leukemia leading to extensive diversity and heterogeneity.
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